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Second Avenue is located on the East Side of the New York City borough of Manhattan extending from Houston Street at its south end to the Harlem River Drive at 128th Street at its north end. A one-way street, vehicular traffic on Second Avenue runs southbound (downtown) only, except for a one-block segment of the avenue in Harlem. South of Houston Street, the roadway continues as Chrystie Street south to Canal Street.

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