Makati Science High School (Filipino: Mataas na Paaralang Pang-Agham ng Makati), also known as MakSci, is a public science high school in Cembo, Taguig, Philippines. It is one of three science high schools in the city and is operated, managed, and administered by the Schools Divisions Office of Taguig City and Pateros (SDO-TaPat). Ownership of its land and school building are currently disputed between the cities of Makati and Taguig following the resolution of the Makati–Taguig territorial dispute, which favors Taguig.