Karen Sisco is an American crime drama television series starring Carla Gugino in the title role. The series was created by novelist Elmore Leonard, based on a character who had appeared in several of his written works, as well as one film adaptation, 1998's Out of Sight. The series debuted on October 1, 2003 on ABC, and was canceled after ten episodes, with Gugino later reprising her role from the series in a 2012 third season episode of Justified.
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