Sir George Smith (died 21 March 1619) of Madworthy-juxta-Exeter and Madford House, Exeter, Devon, was a merchant who served as MP for Exeter in 1604, was three times Mayor of Exeter and was Exeter's richest citizen, possessing 25 manors. He was the grandfather of George Monck, 1st Duke of Albemarle (1608-1670) KG and of John Grenville, 1st Earl of Bath (1628–1701).