Clara Tauson defeated Viktorija Golubic in the final, 6–4, 6–1 to win the singles tennis title at the 2021 WTA Lyon Open. It was her first WTA Tour title, and she won it as a qualifier. Tauson did not lose a set during the tournament, including qualifying rounds, and dropped just 35 games across seven matches. Tauson was the second Dane, after Caroline Wozniacki, to win a WTA Tour singles title. The final match was the first WTA singles final to be contested between two qualifiers since the 2017 Japan Women's Open.
