Habsburg Netherlands refers to those parts of the Low Countries that were ruled by sovereigns of the Holy Roman Empire's House of Habsburg. This rule began in 1482 and ended for the Northern Netherlands in 1581 and for the Southern Netherlands in 1797. The rule began with the death in 1482 of Mary of Burgundy of the House of Valois-Burgundy who was the ruler of the Low Countries and the wife of Holy Roman Emperor Maximilian I of Austria. Their grandson, Emperor Charles V, was born in the Habsburg Netherlands and made Brussels one of the capitals in the Spanish Empire.