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Judith's mother's name is Lenore.

Alan's cell phone's ringtone in the beginning of the series is Ludwig van Beethoven's "Für Elise". In later seasons, his ringtone is a possibly covered version of Fifth Dimension's "Up, Up, and Away." One of the show's running gags is Alan's cell phone ringing at unexpected times and places.

Brooke D'Orsay who plays Kate in season 10 also appears as an another character in a previous season.

Before playing Chelsea, Jennifer Taylor played four different women in three different episodes, including the Pilot. (All four were of interest to Charlie in their respective episodes.)

Kimberly Williams-Paisley (Gretchin) and Courtney Thorne-Smith (Lindsay) worked together on sitcom According to Jim (2001).

Filming had to be interrupted during season 7, when Charlie Sheen checked himself into rehab in February 2010. Sheen's time in rehab was related to a domestic violence incident with his wife Brooke Mueller on Christmas Day 2009 after which he was charged with felony menacing, third degree assault, and criminal mischief.

Product placement (seeing a clearly-identifiable product label on a shelf or in a person's hand) is a study in contrasts in this show. In almost every instance where hard liquor is seen, the front label of the container is facing away from the camera. Other products often are disguised or hidden. In Season 5, however, the presence of a can of Cafe Bustelo coffee in the kitchen almost steals the scene away from the actors. (Maybe it's the bright yellow and red label?) In every episode from Two and a Half Men: Media Room Slash Dungeon (2007) (Season 5, Episode 2) to Two and a Half Men: Shoes, Hats, Pickle Jar Lids (2007) (Season 5 Episode 9) a bright, clearly-readable Cafe Bustelo can is on the Harpers' kitchen counter. In Two and a Half Men: City of Great Racks (2007) (Season 5 Episode 4), a large, lighted advertising sign for the product also is seen on the counter of the local coffee shop. (In subsequent episodes after No.9, Cafe Bustelo is not seen again, replaced, it seems, by the more subdued but still recognizable packaging of Don Francisco brand coffee.)

Watch the opening theme song during the later seasons. During the song, Angus T. Jones appears as young as he was during the First Season, but at the end of the song in later season, he "morphs" into the age he is for that particular season.

Charlie's full name is Charles Francis Harper.

Chuck Lorre is a big fan of British punk band, the U.K. Subs (1976 - present), whose lead singer is named Charlie Harper.

While Charlie was a planned baby, where Alan was the result of "a pitcher of margaritas and a gas station condom", said by Evelyn.

Every outfit worn by Rose, without exception, has a rose or pattern of roses.

At a convention of television critics during the summer of 2005, executive producer Chuck Lorre confirmed that the show's opening tune is performed by studio musicians and not by actors Charlie Sheen, Jon Cryer and Angus T. Jones (who merely lip-sync the lyrics). One of the actual crooners is singer and voice-over artist Elizabeth Daily.

Each episode derives its title from a line in the working script.

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