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Alan has been to bed with six women previously dated by Charlie: Sherri (who threw him out before they had sex), Norma, Gretchen, Kandi (whom he married and who divorced him), Melissa and Rose.


Martin Mull (the pharmacist) always asks the question "What? Are you a cop?" Even in other tv shows.


In one episode, it is said that Walden (Ashton Kutcher) is an underwear model. In real life he had a brief career in modeling underwear.


The black ornamental trim on the copper range hood was not there in the first episode.


Every time any of the characters went to see Russell the Pharmacist, he always uses the phrase "What are you a Cop".


Chelsea is from Champaign, Illinois


For a short period of time, Walden used the false name of Sam Wilson. Samuel Wilson (September 13, 1766- July 31, 1854) was a meat-packer from Troy, New York whose name is purportedly the source of the personification of the United States known as "Uncle Sam".


Jake's full name is Jacob David Harper. His birthday is March 14th.


Berta wasnt originally supposed to be a recurring character, but Conchata Ferrell proved to be such a hit with the audience, that she became a regular cast member at the start of season two.


Rose was originally written off near the end of season four by having her move to London, because Melanie Lynskey had landed a part on the FOX pilot, Drive (2007) When that show was canceled, she was allowed to return to Two and a Half Men.


April Bowlby made ten appearances as a guest star in season three. However, when she got bumped up to regular cast member status in season four, she only appeared five times.


Steven V. Silver, the show's cinematographer for the first 10 seasons, also has worked on Mom (2013), Dharma & Greg (1997) and The Big Bang Theory (2007), all of them Chuck Lorre shows.


Though he plays the younger brother on the show, Jon Cryer is actually five months older than Charlie Sheen. Cryer's birthday is April 16, 1965 and Sheen's birthday is September 3, 1965.


It is revealed that Charlie was a planned child whilst Alan was only conceived because Evelyn "didn't want to smear her lipstick." Evelyn also told Alan he was the product of "a pitcher of Margaritas and a gas-station condom".


The opening intro features Ashton Kutcher taking over Angus T. Jones place, with a different vocalist singing.


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