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Who the "2 and a half men" of the show were has changed four times during the shows run: In season 1-8 it was Charlie Sheen (Charlie Harper), Jon Cryer (Alan Harper) and Angus T. Jones (Jake Harper). In season 9-10 it was Ashton Kutcher (Walden Schmidt), Jon Cryer (Alan Harper) and Angus T. Jones (Jake Harper). In season 11 it was Ashton Kutcher (Walden Schmidt), Jon Cryer (Alan Harper) and Amber Tamblyn (Jenny). In season 12 it was Ashton Kutcher (Walden Schmidt), Jon Cryer (Alan Harper) and Edan Alexander (Louis).

However, during the 11th season it was technically "2 men and a half woman". Since it's a very confusing title though, the show continued to be called the same.

Berta's surname isn't revealed.

Chelsea's middle name is Christine.

Hugh Grant was originally signed to replace Charlie Sheen. His character was to be smooth-talking con man who tricks Alan into letting him move in without paying rent. But Grant decided that he did not want to commit to multi-year contract for a television series and backed out of the role.

Dr. Melnick was initially named Greg instead of Herb.

Judy Greer who plays Walden's (Ashton Kutcher) ex-wife since season 9, played a different role in the early season of the show as Herb's sister in one episode

Blythe Danner was the original choice for Charlie and Alan's mother, she appeared in the original unaired pilot. But she reluctantly had to drop out due to other conflicts.

Charlie Sheen (Charlie Harper), Jon Cryer (Alan Harper) and Ryan Stiles (Dr. Herb Melnick) have previously co-starred in the Top Gun (1986) parody Hot Shots! (1991)..

Error: In S10E08 ("Two and a Half Men: Something My Gynecologist Said (2012)") Alan meets his older Alter Ego, Sid Olsen, in a bar. Before Sid leaves he gives Alan his business card with the back side visible before the cut. After the cut the card shows the front side with letters "CPA" in an oval.

In Two and a Half Men: Twanging Your Magic Clanger (2010), the pornographic website Charlie gives Alan when he walks in on him doing his (business) is, if you search this on your browser it will lead you to the official two and a half men Facebook page.

Jon Cryer co-starred in No Small Affair (1984) with Demi Moore who was married to Ashton Kutcher.

Charlie Sheen does not play the piano on the show. He is dubbed by composer Grant Geissman, who plays offstage while Sheen fakes it on a dead keyboard. With composer Dennis C. Brown, Geissman also writes the music for the jingles Sheen's character creates.

From time to time, and usually during the Charlie Sheen days, members of the old "brat pack" would make guest appearances on the show; for example, Judd Nelson appeared as the ex-husband of Alan's girlfriend, also Emilio Estevez and Martin Sheen (Charlie's brother and father, respectively) have made appearances on different episodes, as well as Ally Sheedy.

Charlie Sheen was fired from the show in March 2011. The show went initially on hiatus during filming season 8 due to Sheen undergoing a substance rehabilitation program. However, following what was only supposed to be a short hiatus, Sheen had a highly publicized meltdown. Besides making anti-semitic remarks towards series creator Chuck Lorre, he made bizarre statements in television interviews, suggesting that he was a "warlock" with "tiger blood" and "Adonis DNA", and that he was "winning". He also posted videos to YouTube showing himself smoking cigarettes through his nose, and cursing out his former employers. The dismissal of Sheen caused the show to cease production for the rest of its eighth season. The ninth season started with Ashton Kutcher, who was announced as Sheen's replacement in May 2011, as co-lead with original cast-member Jon Cryer.

In the opening credits, where the theme song of the show is played Jake (Angus T. Jones) is usually seen growing from a young child to what he currently looks like according to the episodes. However in the later episodes of season 9, Walden's hair becomes shorter and his beard disappears at the end of the theme song indicating his recent new look in the show.

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