Three sets of twins and a dummy were used to portray the baby.
Plans for a sequel had already been made before this film was even in theaters.
During filming in Las Vegas, one of the Mercedes (a very beat up and distinctive one) was stolen from the lot where the vehicles were being kept. The next day the production was filming driving sequences and traffic was being held up by the local police. A production person noticed that a very distinctive Mercedes was part of the cars being held, the police were told, the driver was arrested and the car was recovered.
Due to pervasive language and disturbing images, the first theatrical trailer of the movie was digitally altered. It showed Ken Jeong jumps out of the trunk with a digitally added white underpants. Also Bradley Cooper offensive dialog calling Ed Helms was altered. "Paging Dr. Faggot" was changed into "Paging Dr. Douchebag". But later the Red Band version of trailer released without any alternation. See also Pathology (2008).
At one point, Officer Franklin (Rob Riggle) refers to Alan as "Fat Jesus." This is a reference to a Zach Galifianakis joke from his "Comedy Central Presents" (1998), in which he claims, "I look like Fat Jesus...not Phat Jesus."
Bradley Cooper and Justin Bartha's third film together, after Failure to Launch and New York, I Love You.
One of the songs from the movie is "Can't Tell Me Nothing" by Kanye West. One of the stars, Zach Galifianakis was actually paid by West to make an alternative music video for the song.
No effects or prosthetics were created for Stu's missing tooth. Actor Ed Helms never had an adult incisor grow, and his fake incisor was taken out for the parts of filming where Stu's tooth is missing.
According to Celena Haas (Caesars Palace Director of Public Relations), the suite the characters stayed at was modeled after two of the resort's luxurious suites in its Forum Tower: a well-appointed penthouse and the so-called "Rain Man suite," located on the 68th and 69th floors of the Forum Tower.
Todd Phillips waived his usual salary and received part ownership of the film instead. In an interview with Howard Stern, Phillips said that due to the film's box-office success "this is his Star Wars."
Lindsay Lohan was offered the part of the stripper, Jade, but turned it down. She did not like the script and thought the movie would bomb. Heather Graham was given the role instead. Lohan later admitted to regretting the decision.
Ed Helms (Stu), Rachael Harris (Melissa), Rob Riggle (Officer Franklin) and Matt Walsh (Dr. Valsh) all appeared as correspondents on The Daily Show.
Due to the physicality of his role, Ed Helms lost a reported 8lbs in weight.
An actual taser was originally going to be used in the taser scene, but lawyers from Warner Bros. demanded that the crew use a prop.
Highest grossing R-rated comedy in the U.S. to its release date.
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