Minneapolis ( ) is the largest city in the U.S. state of Minnesota and the principal city of the 16th-largest metropolitan area in the United States. As of 2018, Minneapolis has an estimated population of 425,403, making it the 46th-largest city in the United States. Minneapolis and its neighbor Saint Paul make up the Twin Cities, with Minneapolis being the larger of the two. The Twin Cities metro and their surrounding suburbs contain about 3.63 million people, making it the third-largest economic and population center in the Midwest. Minneapolis is the county seat of Hennepin County.