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Has two older brothers, Holt and John; and older sister, Meg. Brother Jason died from head injuries suffered in a car accident when she was very young.

1999: Auditioned for all 3 female leads on "Roswell" (1999) before being cast as Isabel.

She is half Irish and half German.

1994: Beat out Alicia Silverstone for the lead role in My Father the Hero (1994).

Her last name is pronounced "HI guhl."

Katherine has played a character with the name of "Isabel/Isobel" three times. "Grey's Anatomy" (2005), "Roswell" (1999) and Wuthering Heights (2003) (TV).

In Judd Apatow's film, The 40 Year Old Virgin (2005), the FHM "100 Sexiest Women in the World 2005" special supplement with Katherine on the cover is shown in close-up during a scene on the extended version DVD. Katherine plays the lead in Apatow's follow-up, Knocked Up (2007).

2007: Ranked #14 on the Maxim magazine Hot 100 of 2007 list.

2007: Was writer/director Judd Apatow's first choice for the lead role in Knocked Up (2007).

Best friend of her "Grey's Anatomy" (2005) co-star T.R. Knight, who was a groomsman at her wedding.

Katherine is related to actress Amber Perkins.

Auditioned for the role of Felicity Porter in the TV series "Felicity" (1998), but lost out to Keri Russell. She also auditioned for the roles of Sydney Bristow and Lauren Reed on "Alias" (2001), but lost out to Jennifer Garner and Melissa George, respectively.

2007: Was named one of Entertainment Weekly's Top 25 Entertainers Of The Year.

2006 June: Engaged to musician Josh Kelley.

1994: Began dating Joseph Lawrence. They met at Seventeen Magazine's 50th Anniversary party.

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