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She jokingly lamented that during filming of The Big Shot (1942) she never got to share romantic moments but not a filmed kiss with her co-star Humphrey Bogart, but that she had to take a bullet for him anyway during the final reel.
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Penned a column while living in London entitled "Girl About Town".
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Her first husband, Het Mannheim, was the Head of Publicity at Republic Studios in 1937 where she filmed her first picture with Gene Autry. He changed her stage name from Hope Manning to Irene Manning. They later married but their long distance relationship ended soon in divorce.
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Came from a musical family. Her parents were singers. Irene sang, as well, and both she and a sister played piano. Her two brothers played the violin and another sister the cello and a clarinet.