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Similarities between Katherine Heigl's characters in Roswell and Grey's Anatomy: in each her character, Isabel/Isobel, has a pivotal scene in a pink, strapless gown, has a love interest named Alex, sees, talks to and dances with a dead lover, and is extremely fussy about the holidays.

T.R. Knight left the show at the end of season 5, because he felt that his character George O'Malley wasn't given enough storyline or on-screen time throughout the season. He said that there was a "breakdown in communication" between him and creator Shonda Rhimes. Instead of making any demands, he just asked to be written out of the show.

Alex was the first person to refer to George as "007".

The first person to refer Dr. Sloane as "McSteamy" was Meredith.

Karev's full name is Alexander Michael Karev.

Izzie's full name is Isobel Catherine Stevens.

Katherine Heigl dropped herself out of Emmy consideration in 2008, because she felt that she wasn't given the material that would warrant a nomination.

The character name Dr. Mark Sloan is a reference to a 'Dick Van Dyke' character by the same name in the TV show '"Diagnosis Murder" (1993)'.

Kate Walsh's character, Addison Shepherd, was only supposed to appear in 5 episodes, but quickly developed a fan base so they kept her on.

Cristina's stepfather is Jewish.

Dr. Cristina Yang is an MD-PhD.

The first person to refer to Dr. Shepherd as "McDreamy" was Cristina.

Dr. Meredith Grey lives on 613 Harper Lane.

Christina attended Stanford University and graduated first in her class.

Meredith went to Dartmouth College.

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