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Dr. Isobel "Izzie" Stevens: I'm a pretty girl. Dr. Richard Webber: What? Dr. Isobel "Izzie" Stevens: I'm not being arrogant, it's just... it's just kinda a fact. For a long time I made a career for my looks, so I get it. I'm a pretty girl. And not from a certain angle way, in an obvious way. It's the blonde thing, and the big boobs thing. Big boobs are key to obvious pretty, if you know what I'm saying. Dr. Richard Webber: Dr. Stevens... Dr. Isobel "Izzie" Stevens: That's how men see me. I'm not a smart girl or an interesting girl. I'm a pretty girl. The blonde and the boobs confuses guys into thinking that I'm someone else. And I'm used to it. I'm used to them walking away when they realize... but then Denny goes and asks me to marry him. Dr. Richard Webber: Is that why you cut the wires? Dr. Isobel "Izzie" Stevens: He doesn't make me feel like I'm a pretty girl. He makes me feel like... like me. I think he might know me. And so if I did cut the L-Vad wire, and I'm not saying I did, but if I did then no. I don't feel guilty. And I know that I should and I would if it were anybody else. But I can't feel anything but happy.

Dr. Derek Shepherd: So, who's next, Alex? He likes to sleep around... you two have that in common. Dr. Meredith Grey: You don't get to call me a whore! When I met you, I thought I had met the person I would spend then rest of my life with. I was done. So all the boys, and all the bars, and all the obvious daddy issues... who cared? Because I was done. You left me! You chose Addison! I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore!

Dr. Meredith Grey: At the end of the day, when it comes down to it, all we really want is to be close to somebody. So this thing, where we all keep our distance and pretend not to care about each other, is usually a load of bull. So we pick and choose who we want to remain close to, and once we've chosen those people, we tend to stick close by. No matter how much we hurt them, the people that are still with you at the end of the day - those are the ones worth keeping. And sure, sometimes close can be too close. But sometimes, that invasion of personal space, it can be exactly what you need.

Dr. Meredith Grey: The fantasy is simple. Pleasure is good. And twice as much pleasure is better. That pain is bad. And no pain is better. But the reality is different. The reality is that pain is there to tell us something. And there is only so much pleasure we can take without getting a stomachache. And maybe that's okay. Maybe some fantasies are only supposed to live in our dreams.

Dr. Miranda Bailey: Look at this. Everybody wants a life without pain. And what does it get you? She needs to be on a poster somewhere to remind people, pain is there for a reason.

Denny Duquette: I've been lying in this bed for close to a year, and I've had a lot of time to look back on my life. And the things that I remember best - those are the things I wasn't supposed to do and I did them anyway. The thing is, life is too damn short to be following these rules.

Dr. Addison Shepherd: (Addison is annoyed that Derek has just caught a trout and has brought it inside) Why did you bring a trout into the trailer?

Dr. Derek Shepherd: I'm cooking the trout outside the trailer. Dr. Addison Shepherd: I still hate the freaking trailer.

Dr. Addison Shepherd: I hate this freaking trailer! Dr. Derek Shepherd: Fine then. No trout for you.

Dr. Derek Shepherd: (to Addison) Christmas makes you want to be with people you love. I'm not saying this to hurt you, or because I want to leave you, because I don't. Meredith wasn't a fling. She wasn't revenge. I fell in love with her. That doesn't go away because I decided to stay with you.

Dr. Derek Shepherd: Do you happen to know what time of year neurosurgeons are the busiest, Dr. Stevens? Dr. Isobel "Izzie" Stevens: There's a time of year? Dr. Derek Shepherd: There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Like our friend here. Folks fall off their roofs while they string up lights. Or they go skating for the first time in a decade and break their heads open. And every year people drive through blizzards to get to parties where they kiss germ-infected strangers under poisonous mistletoe. And then they get so drunk that they smash their heads through their windshield on their way home. Like I said, there's no hard or fast rule.

Dr. George O'Malley: (talking to himself) Oh, hi, chief. Nope, not much going on, well, other than your intern chief making out with my friend in the stairwell, but hey... sponge duty sucks. Dr. Meredith Grey: (walks up beside him) Talking to yourself now? Dr. George O'Malley: Yes. No. (pause) Dr. George O'Malley: Damn it. I'm a bad sponge. A leaky sponge. I'm gonna leak all the wrong secrets. I'm a bad liar. I can't even lie about talking to myself.

Dr. Meredith Grey: Communication. It's the first thing we really learn in life. Funny thing is, once we grow up, learn our words and really start talking the harder it becomes to know what to say. Or how to ask for what we really need.

Dr. Meredith Grey: How do you know when how much is too much? Too much too soon. Too much information. Too much fun. Too much love. Too much to ask... And when is it all just too much to bear?

Dr. Meredith Grey: When you were a kid, it was Halloween candy. You hid it from your parents and you ate it until you got sick. In college, it was the heavy combo of youth, tequila and well, you know. As a surgeon, you take as much of the good as you can get because it doesn't come around nearly as often as it should. 'Cause good things aren't always what they seem. Too much of anything, even love, is not always a good thing.

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