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George Clooney had his first regular TV role in a comedy ten years earlier called "E/R" (1984).

Carol Hathaway (Julianna Margulies) was supposed to be brain-dead from a suicide attempt in the first episode, but the character was revived for the series. For the first episode, Margulies was credited as a guest star.

In one episode, Dr. Lewis admits that she's only familiar with the Walt Whitman poem "I Sing the Body Electric" because it appeared in song form in the movie Fame (1980). That song in that film was sung by Paul McCrane (Dr. Romano).

Noah Wyle was the last member of the original cast to leave, at the end of the 2004-2005 season. He will appear occasionally in future seasons. Sherry Stringfield is also an original cast member, but she left for 5 seasons, which made Noah Wyle the only cast member to be on the show every year for the series first eleven seasons.

Including Gloria Reuben and CCH Pounder (who appeared as recurring guest stars during the first season), the original cast combined for 25 nominations in the Leading and Supporting Acting categories at the Emmy Awards from 1995-2000. Julianna Margulies (Best Supporting Actress, 1995) was the only one to ever win.

The first four episodes of the show all began the same way, with one of the doctors being awakened early in the morning from "Exam 8" at the end of the hallway in this order: Greene (Pilot), Lewis (Day One), Benton (Going Home), Carter (Hit and Run). This became a recurring motif throughout the run of the series, and the 200th episode began this way as well. Of the original five doctors, Ross (George Clooney) was the only one who was never shown sleeping in Exam 8.

The very first person to appear on-screen in the first episode is Anthony Edwards.

Glenne Headly was pregnant when she signed on to do her story arc as Dr Abby Keaton in the third season. Originally the writers floated the idea of writing the pregnancy into the show but then decided that audiences would have difficulty accepting John Carter having a relationship with a heavily pregnant woman. In the later stages, Headly had to be photographed behind gurneys and in ill-fitting surgical scrubs to hide her bump.

Seasons Seven and Fourteen are the only seasons to not have a cast change.

The entire main cast of the first season also appeared in the fifteenth and final season: Anthony Edwards, Noah Wyle, George Clooney, Eriq La Salle, Sherry Stringfield, and Julianna Margulies.

Anthony Edwards, Paul McCrane, Laura Innes, and Eriq La Salle are the only cast members to direct episodes throughout the shows fifteen season run. In fact Paul McCrane directed an episode not long after "Romano" was killed.

All original cast members who appeared in Season 15 were listed in the credits with the current stars, not as guest appearances. 'Alex Kingston' and 'Laura Innes' also appeared in the opening credits to the series finale due to their roles in it. In the 2009 episode guest starring George Clooney and Julianna Margulies, Noah Wyle received top billing over both of them.

Dr. Chen is the only character to repeatedly call Carter by his first name.

Abby is the only character to have been both a nurse and a doctor.

When the show debuted in 1994 it won the People's Choice Award for 'Favorite Dramatic Series' every year until 2002. It has also won the George Foster Peabody Award.

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