| Shaun Evans | DS Endeavour Morse, associate producer / executive producer , | |
| Roger Allam | DI Fred Thursday, associate producer / executive producer | |
| James Bradshaw | Dr. Max DeBryn | |
| Sean Rigby | DS Jim Strange | |
| Anton Lesser | Chief Superintendent Reginald Bright | |
| Caroline O'Neill | Win Thursday | |
| Abigail Thaw | Dorothea Frazil | |
| Sara Vickers | Joan Thursday | |
| Dakota Blue Richards | WPC Shirley Trewlove | |
| Jack Laskey | DS Peter Jakes | |
| Jack Bannon | Sam Thursday | |
| Shvorne Marks | Monica Hicks | |
| Carol Royle | Mrs. Bright | |
| Richard Riddell | DS Alan Jago | |
| Mark Arden | Eddie Nero | |
| Stephanie Leonidas | Violetta Talenti | |
| Alison Newman | Viv Wall | |
| Ryan Gage | Ludo Talenti | |
| Phil Daniels | Charlie Thursday | |
| Richard Harrington | Dr. Dai Ferman | |
| Holli Dempsey | Jenny Tate | |
| David Reed | Julian Calendar | |
| Robin Lermitte | Bursar | |
| Joanna Horton | Linda Snow | |
| Danny Webb | DI Arthur Lott | |
| Rebecca Saire | Hazel Radowicz | |
| John Hollingworth | Dan Lofthouse | |
| James Doherty | Mr. Lee | |
| David Jonsson | Cromwell Ames | |
| Simon Kunz | DI Bart Church |
