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Actor Timothée Chalamet was 23 when he played Paul Atreides, two years younger than Kyle MacLachlan when he played the same role in Dune (1984).

This is the second collaboration between Javier Bardem and Josh Brolin, after appearing together in No Country for Old Men (2007).

Both Javier Bardem & Dave Bautista have played antagonists in a Daniel Craig "James Bond movie". Bardem played the main antagonist, Raoul Silva in Skyfall (2012) while Bautista played an assassin, Mr Hinks in Spectre (2015).

Denis Villenueve, the director of this film also directed Blade Runner 2049 (2017). Actress Sean Young appeared in the previous installments of both films, Dune (1984) and the original Blade Runner (1982).

Alejandro Jodorowsky's script for Dune was a major inspiration for Star Wars: Episode IV - A New Hope (1977). Oscar Isaac is now the second Star Wars cast member to appear in an adaptation of Dune. David Lynch's film featured Max von Sydow.

This is the second collaboration between Rebecca Ferguson and Zendaya, after appearing together in The Greatest Showman (2017).

This is Dave Bautista and Denis Villeneuve's first collaboration since Blade Runner 2049 (2017).

Denis Villeneuve previously directed Blade Runner 2049 (2017) for producer Ridley Scott. Scott was at one point planning to direct an adaptation of Dune. His own film Alien (1979) was written by Dan O'Bannon and designed by H.R. Giger, Chris Foss, Jean Giraud and Ron Cobb, who had all met each other while working on Alejandro Jodorowsky's failed Dune project, and brought much of their design works for Dune to Alien.

Josh Brolin, Stellan Skarsgård, Dave Bautista, Zendaya and David Dastmalchian all have appearances in the Marvel Cinematic Universe.

Stellan Skarsgård is the third Swede to appear in an adaptation of Dune. Max von Sydow appeared in David Lynch's film. Skarsgard also appeared in Dominion (2005) and Exorcist: The Beginning (2004), as the younger version of Von Sydow's character from The Exorcist (1973).

Stellan Skarsgård and Dave Bautista both appeared in the Marvel Cinematic Universe. Skarsgard appeared in Thor (2011) and The Avengers (2012), while Batista appeared in Guardians of the Galaxy (2014) and Avengers: Infinity War (2018). The latter film also featured William Hurt, who appeared in Dune (2000). The original Dune (1984) also featured José Ferrer, whose son Miguel Ferrer appeared in Iron Man Three (2013). The 1984 original and 2003's Children of Dune (2003) also featured Patrick Stewart and James McAvoy, who have both played Charles Xavier in the Marvel-based X-Men series.

Denis Villeneuve's first time producing one of his films.

Denis Villeneuve confirmed that his adaptation of Dune (2020) will be split into at least two films, in order to ensure that the original story would be "preserved and not cut into a million pieces."

Denis Villeneuve third consecutive science fiction film, after Arrival (2016) and Blade Runner 2049 (2017)

Charlotte Rampling, who will star in Denis Villeneuve's upcoming adaptation of the 1965 novel, originally wanted to play Lady Jessica in Alejandro Jodorowsky's failed Dune project, but declined the offer due to a scene that involved 2,000 extras defecating at once.

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