| Alan Rickman | Hilly Kristal, performer: "Birds and the Bees" | |
| Malin Akerman | Debbie Harry | |
| Justin Bartha | Stiv Bators | |
| Richard de Klerk | Taxi | |
| Johnny Galecki | Terry Ork | |
| Kyle Gallner | Lou Reed | |
| Ashley Greene | Lisa Kristal | |
| Rupert Grint | Cheetah Chrome | |
| Estelle Harris | Bertha Kristal | |
| Taylor Hawkins | Iggy Pop | |
| Ryan Hurst | Mad Mountain | |
| Stana Katic | Genya Ravan | |
| Joel David Moore | Joey Ramone | |
| Ahna O'Reilly | Mary Harron | |
| Freddy RodrÃguez | Idaho | |
| Mickey Sumner | Patti Smith | |
| Bradley Whitford | Nicky Gant | |
| Josh Zuckerman | John Holmstrom | |
| Julian Acosta | Johnny Ramone | |
| Arthur Bridgers | Shamai Kristal | |
| Jared Carter | David Byrne | |
| Cheetah Chrome | Cabbie, special thanks, writer: "Caught with the Meat in Your Mouth", "Sonic Reducer", "Ain't Nothin' to Do" | |
| Darin Heames | Bert | |
| Vincenzo Hinckley | Da Thug | |
| Donal Logue | Merv Ferguson | |
| Michael Massee | Officer Stan | |
| Aaron Munoz | Palace Hotel Manager | |
| Tom Nowicki | Palace Bartender | |
| Steven Schub | Dee Dee Ramone | |
| Peter Vack | Legs McNeil |
