La La became engaged to basketball player Carmelo Anthony on Christmas Day 2004. Their son, Kiyan Carmelo Anthony, was born on March 7, 2007. They were married by Michael Eric Dyson on July 10, 2010, at Cipriani's in New York before 320 guests. The ceremony was filmed by VH1 and aired as part of a reality series on the couple, titled La La's Full Court Wedding. The couple's life together is chronicled on their continuation series, La La's Full Court Life.
In April 2017, La La filed for separation from her husband after he was publicly accused of impregnating a woman employed at a gentlemen's club. However, in a June 2017 interview on The Wendy Williams Show, La La said that she and Carmelo are not officially divorcing at the moment.