[Malipiero] began working as a model, and then made her debut as an actress in film and television. In 1989, she went with her mother to the United States, and won the title Mother & Daughter, a beauty pageant, similar to Miss Universe, involving pairs of mothers and daughters. In 1990 she also participated in Miss Universe as Miss Italy.
After several roles in films and TV dramas, she becomes known to the public thanks to the role of the evil Rebecca Sarpi, played from 2002 to 2008 on the soap opera of Channel 5, Living.
Since June 20, 2012 she joined the cast of the soap Centovetrine recurring in the role of Maddalena Sterling.
She was for eight years the companion of actor Francesco Nuti, with whom she had a daughter in 1999, Geneva, after which she was linked to industrial Saturnino De Cecco and then to the dentist Bindelli Mark, with whom she had children Lucrezia and Leonardo . Currently, she was reported to be engaged to actor Luciano Roman, they met on the set of Living.