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Stephen Collins (Eric Camden) and Beverley Mitchell (Lucy Camden) are the only actors to appear in all 243 episodes.

The song "Anything You Want" was played at the very beginning of the very first episode of the show and it was also played again at the end of the last episode of season 10 (which at the time was the end of the show for good).

# # The show was originally going to end after 10 seasons but after the series finale aired, The CW network renewed the show at the last minute and the series finale was changed to the 10th season finale.

Out of the four original series to debut on The WB's launch season, this show was the only show to get renewed beyond its first year.

While the exterior of the house used is actually a real house, interiors are filmed on sound stages in West Los Angeles.

# # Series co-star George Stults got the role of Kevin Kinkirk through the help of his younger brother (actor Geoff Stults) who had guest starred on the series several times before George was approached to join the cast as Lucy (Beverley Mitchell)'s love interest.

# # When the role of Martin Brewer (Tyler Hoechlin), the son of an U.S. soldier originally went out to be cast in May 2003 for the next season the character's original name was Joe. He was also supposed to be a bad kid who would create a lot of trouble for Ruthie Camden (Mackenzie Rosman) and the rest of her family. Although, once actor Tyler Hoechlin was cast in the role they changed the name of the character as well as the personality of the character to fit more into the family fold.

# # In real life Beverley Mitchell (Lucy Camden) is older than her co-star Jessica Biel (Mary Camden). But on the show Jessica Biel's character Mary is the older sister, while Beverley Mitchel's character Lucy is the younger sister.

# # Barry Watson (Matt Camden) is the only series regular to have ever written (7.8 "Peer Pressure") and also direct an episode (9.16 "Brother Love") of the series.

# # The fictional town of Glen Oak where the series is based in is supposed to be located somewhere in Southern California, according to series creator Brenda Hampton.

# # In the 7th season series creator Brenda Hampton created the role of Chandler Hampton (played by Jeremy London) and purposely gave the character her last name to fit more into the show as Rev. Eric Camden's ('Stephen Collins') associate pastor.

# # Writer 'Ron Zimmerman' who wrote episodes for the series in its first season later on became a recurring character on the series as the character Doc, a cancer surviving patient that Camden family befriends.

Stephen Collins (Reverend Eric Camden) was offered the role of Eric Camden two days before the pilot episode was filmed. He never auditioned for the role. The next day he met the entire cast in Aaron Spelling's office and read the script out loud with them. It was then when he accepted the role.

During the fourth and fifth season of the series there was much controversy over co-star Jessica Biel's (Mary Camden) unhappiness over the show and her character Mary. She attempted to leave the show by getting fired when she posed for Gear Magazine to upset producers and network executives to let her out of her contract - which she'd later regret, as she admitted in later interviews and was now contented with the series.

Series creator Brenda Hampton got the idea of Rev. Eric Camden and his wife Annie Camden becoming pregnant and having twins in the third season from her sister who had recently given birth to twins at the time.

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