People from Panama City

Jordana Brewster (born April 26, 1980) is an American actress and model. She made her acting debut in an episode of All My Children in 1995 and next took on the recurring role as Nikki Munson in As the World Turns, garnering a nomination for Outstanding Teen Performer at the 1997 Soap Opera Digest Award. Her first role in a feature film was in Robert Rodriguez's horror science fiction The Faculty (1998).

Luis Miguel González Bosé (born April 3, 1956), usually known as Miguel Bosé, is a Spanish pop new wave musician and actor.

Patricia Michelle de León (born in Panama City, Panama) is a Panamanian actress, TV host, model and beauty pageant title holder. She started working as a model at an early age. After being crowned Miss Panama (1995), she hosted La Corte de Familia and La Corte del Pueblo on Telemundo. She was also featured on Juez Franco on TV Azteca, and the Billboard Latino. From her work on Univision, de Leon obtained roles on American TV, including Lincoln Heights, Cold Case, and Crossing Jordan. Her movie role include The Pool Boys (where she plays the Latina Julia).

Carolina Dementiev Justavino (born 1 February 1989) is a Panamanian model, TV host, ironman and beauty pageant contestant winner of the Miss Panama pageant. She also represented Panama in the 57th Miss Universe 2008, held at the Diamond Bay Resort in Nha Trang, Vietnam.

Daphne Rubin-Vega (born November 18, 1969) is a Panamanian-American dancer, singer-songwriter, and actress. She is best known for originating the roles of Mimi Marquez in the Broadway musical Rent and Lucy in the Off-Broadway play Jack Goes Boating.

Mariano Rivera (born November 29, 1969) is a Panamanian-American former professional baseball pitcher who played 19 seasons in Major League Baseball (MLB) for the New York Yankees, from 1995 to 2013. Nicknamed "Mo" and "Sandman", he spent most of his career as a relief pitcher and served as the Yankees' closer for 17 seasons. A thirteen-time All-Star and five-time World Series champion, he is MLB's career leader in saves (652) and games finished (952). Rivera won five American League (AL) Rolaids Relief Man Awards and three Delivery Man of the Year Awards, and he finished in the top three in voting for the AL Cy Young Award four times. He was inducted into the Baseball Hall of Fame as part of its class of 2019 in his first year of eligibility, and was the first player ever to be elected unanimously by the Baseball Writers' Association of America (BBWAA).

Félix Danilo Gómez Bosquez (born August 26, 1980), known by his stage names Flex and Nigga, is a Panamanian reggaeton singer and songwriter. He adopted the name Nigga after being told by another Panamanian artist that he "sings like a black guy from Jamaica." Before releasing an album in the United States in 2008, Flex removed references to his nickname in songs, and his CD packages were reprinted with the name "Flex."

Luis Alberto Blanco Saavedra (born 8 January 1978) is a retired Panamanian football midfielder.

Yostin Lissette "Justine" Pasek Patiño (born 27 August 1979) is a Polish-Panamanian model, philanthropist, and beauty pageant titleholder who was crowned Miss Universe 2002. Originally the first runner-up at the Miss Universe 2002 competition, Pasek became the first ever runner-up to be crowned the winner after the dethronement of original winner Oxana Fedorova.

Raiza Patricia Erlenbaugh Soriano, (born 6 March 1991, Panama City, Panama) is a Panamanian model and beauty pageant contestant winner of the Miss Panama World 2014 title on 8 April 2014 for Miss World 2014 contest. On November 12, 2014 she was dethroned as Miss World Panamá 2013 by the Miss Panamá Organization.