Manx emigrants to the United States

Elizabeth Holloway Marston (February 20, 1893 – March 27, 1993) was an American attorney and psychologist. She is credited, with her husband William Moulton Marston, for the development of the systolic blood pressure measurement used to detect deception; the predecessor to the polygraph.

Laura Burt (September 16, 1872 - October 16, 1952) was a British-born actress known for her American and English stage performances.

Florence Roberts (March 16, 1861 – June 6, 1940) was an American actress of the stage and in motion pictures.

Routh Goshen, born Arthur James Caley (1824 – February 12, 1889) was most commonly known as Colonel Routh Goshen or the Arabian Giant or the Palestine Giant. He was billed as the tallest man in the world at 7 ft, 11 inches (2.41 m) and 620 pounds (280 kg) but was most likely no more than 7 ft, 5 inches (2.26 m) and 400 pounds (180 kg). His true origins were kept secret from the public during his performance years in the United States and were obscured by the many apocryphal biographies that were created to publicize him. His actual origins came out slowly after his death. His birth name was Arthur James Caley and he was born on the Isle of Man in 1824. His fictional biographies said he was born in Jerusalem on May 5, 1837. After his retirement in the 1880s, he settled in Middlebush, New Jersey and gained the nickname the Middlebush Giant.

William Garrett (February 6, 1842 – December 30, 1916) was a Manx-born American soldier who fought in the American Civil War. Garrett received his country's highest award for bravery during combat, the Medal of Honor. Garrett's medal was won for his actions in the Battle of Nashville in Nashville, Tennessee, on December 16, 1864. He was honored with the award on February 24, 1865.

William Kennish (1799 – March 19, 1862) was an engineer, inventor, explorer, scientist, and poet, known primarily for inventions developed while he served in the British Royal Navy (1821–1841). They ranged from improvements for artillery to navigation and steering devices.

Jeremiah McGuire (1823 in Isle of Man – October 25, 1889 in Elmira, Chemung County, New York) was an American lawyer and politician.

John Thomas Caine (January 8, 1829 – September 20, 1911) was a delegate to the United States House of Representatives from the Territory of Utah.

Christopher Bryan Robert "Chris" Stott (born July 1969) is a Manx-born American space entrepreneur. He is best known for co-founding the regulatory and orbital frequency services company, ManSat, Odyssey Moon, and the International Institute of Space Commerce.

William H. Corlett (1856 – October 7, 1937), also known as W. H. Corlett, was an American architect and contractor active in Napa County, California and the surrounding area. Several buildings and residences he designed are listed on the National Register of Historic Places.