Destrehan High School alumni

Shelley Catherine Hennig (born January 2, 1987) is an American actress and model. She is the recipient of several accolades, including a Teen Choice Award and two Daytime Emmy Award nominations.

Edward Earl Reed Jr. (born September 11, 1978) is an American former professional football player who was a safety in the National Football League (NFL), spending the majority of his career with the Baltimore Ravens. He played college football for the University of Miami, where he was a two-time consensus All-American. He was drafted by the Ravens in the first round of the 2002 NFL Draft and played 11 seasons for Baltimore before playing with the Houston Texans and New York Jets in 2013.

Justin Jefferson (born June 16, 1999) is an American football wide receiver for the Minnesota Vikings of the National Football League (NFL). He played college football at LSU and was drafted by the Vikings in the first round of the 2020 NFL Draft. He set an NFL rookie record for receiving yards with 1,400 and was named to the Pro Bowl.

Damaris Keith Johnson (born November 22, 1989) is a former American football wide receiver and return specialist for the BC Lions of the Canadian Football League (CFL). After playing college football for the Tulsa Golden Hurricane, he was signed by the Philadelphia Eagles as an undrafted free agent in 2012.

Rusty Rebowe (born January 17, 1956) is a former professional American football linebacker in the National Football League (NFL) for the New Orleans Saints and in the Canadian Football League (CFL) with the Hamilton Tiger-Cats.

Burnell Joseph Dent (born March 16, 1963 in New Orleans, Louisiana) is a former professional American football linebacker in the National Football League (NFL).

Darryl Richard II (born June 17, 1986) is a former American football defensive tackle. He was drafted by the New England Patriots in the seventh round of the 2009 NFL Draft. He played college football at Georgia Tech.

Jamall Johnson (born October 12, 1982) is a former gridiron football linebacker. He was signed by the Cleveland Browns as an undrafted free agent in 2005. He played college football at Northwestern State and high school football at Destrehan High School.

Jeremy Michael Parquet (born April 11, 1982) is a former professional gridiron football player. He was drafted by the Kansas City Chiefs in the seventh round of the 2005 NFL Draft. He played college football at Southern Mississippi.

Rondell Christopher Mealey (born February 24, 1977) is a former American football running back in the National Football League.