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The House of Colonna, is an Italian noble family, forming part of the papal nobility. It played a pivotal role in medieval and Renaissance Rome, supplying one pope (Martin V), 23 cardinals and many other church and political leaders. Other notable family members are Vittoria Colonna, close friend of Michelangelo, Marcantonio II Colonna (Marcantonio Colonna), leader of the papal fleet in the Battle of Lepanto (1571) and Costanza Colonna, patron and protector of Caravaggio. The family was notable for its bitter feud with the Orsini family over their influence in Rome, which was eventually settled by the issuing of the papal bull Pax Romana by Pope Julius II in 1511. In 1571, the heads of both families married nieces of Pope Sixtus V. Thereafter, historians recorded that "no peace had been concluded between the princes of Christendom, in which they had not been included by name". Today, the family is led by Don Prospero Colonna (b.1956).