Characters designed by Shigenori Soejima

Ren Amamiya, also better known as Joker, is the main protagonist of Persona 5, a 2016 role-playing video game by Atlus. He is a second-year high school student who is expelled due to being falsely accused of assault by a corrupt politician. As a result, he leaves his hometown and moves in with a family friend in Tokyo to serve a one-year probation. Upon transferring to a new school, he and a group of other students awaken to a supernatural power known as the Persona.

Haru Okumura (奥村 春, Okumura Haru), also known by her Phantom Thief name Noir, is one of the main characters in the 2016 video game Persona 5. She is a member of the vigilante group, the Phantom Thieves of Hearts, and one of the final members to join the group.

Mitsuru Kirijo (桐条 美鶴, Kirijō Mitsuru) is a fictional character in the Persona series, appearing as a main character in Persona 3. She is the unofficial leader of an organization called SEES (Special Extracurricular Execution Squad), which the main characters of the game participate in to fight creatures called Shadows.

Suguru Kamoshida (Japanese: 鴨志田 卓, Hepburn: Kamoshida Suguru) is a fictional character in the 2016 video game Persona 5. He is the first antagonist that the protagonist, Joker, faces, being a champion volleyball player and current high school coach, who is routinely protected from scrutiny. He regularly exerts violence against multiple characters, including Ryuji Sakamoto and Ann Takamaki, and preemptively discredits anyone he deems a threat, including Joker. He uses his position to abuse male students and sexually harass female students, including Ann's friend, Shiho Suzui, who attempts suicide as a result. He is one of several characters with a Palace, a manifestation of strong desires, where he is depicted as the king of a castle. The principal's failure to protect Shujin Academy's students from him leads to the formation of the Phantom Thieves of Hearts, kickstarting the events of the game.

Ann Takamaki (高巻 杏, Takamaki An, Anne Takamaki in the Japanese version) is one of the main characters in the 2016 video game Persona 5. She is a Japanese-American teenage girl and a second-year student at the fictional Shujin Academy. She is also one of the founding members of the Phantom Thieves of Hearts, a group formed with the intention of stopping wrongdoers from hurting others.

The protagonist (Japanese: 主人公, Hepburn: shujinkō) is a character from Persona 3, a 2006 role-playing video game developed by Atlus. In the game, the protagonist is an orphan who transfers to Gekkoukan High School in Iwatodai City and discovers a phenomenon called the Dark Hour during which supernatural entities called Shadows roam freely. After awakening an ability called Persona, the protagonist joins their classmates in forming the Specialized Extracurricular Execution Squad (S.E.E.S.), dedicated to eliminating the Dark Hour and the threat of the Shadows. In the original release of Persona 3 as well as the updated versions Persona 3 FES and Persona 3 Reload, the protagonist is male; for Persona 3 Portable, Atlus added the option to play as a female, to provide more options to returning players and attract a new female demographic.

Futaba Sakura (佐倉 双葉, Sakura Futaba) is a fictional character in the 2016 video game Persona 5 as one of its main characters. She starts the game as a shut-in who does not go to school, leave her house, or have any friends, due to the grief and self-loathing she experienced over her mother, Wakaba Isshiki, seemingly taking her life and blaming Futaba for it. She is adopted by Sojiro Sakura. She is first anonymous, seeking to utilize the protagonist and his group, the Phantom Thieves of Hearts, to cure her of her issues, which included suicidal ideation, which is accomplished somewhat by discovering that her mother did not commit suicide. She eventually joins the Phantom Thieves, and is one of multiple female characters the player-character Joker can date. While the others are directly playable, she serves as a navigator who assists them in combat.

Chie Satonaka (里中 千枝, Satonaka Chie) is a fictional character from the 2008 video game Persona 4. There she appears as a high school student who starts investigating a dimension labeled as the TV World alongside her friends. The kidnapping of her best friend Yukiko Amagi leads Chie to join the Investigation Team in working in a murder case where the victims are sent to the TV World to be killed by creatures known as Shadows.

Ryuji Sakamoto (坂本 竜司, Sakamoto Ryūji) is a fictional character in the 2016 video game Persona 5. He is one of the Phantom Thieves of Hearts, and one of the first to join the group after awakening to his Persona, Captain Kidd, adopting the Phantom Thief nickname Skull. He is a bullied student, a victim of physical abuse by one of the game's antagonists, Suguru Kamoshida. He joins with the protagonist, Joker, after they both found themselves entering another world and eventually gain powers to fight against corrupt people and abusers, including Kamoshida. His Persona eventually transforms into the Persona Seiten Taisei. He is portrayed by Max Mittelman in English, who was discovered by Atlus for his role in Shin Megami Tensei IV: Apocalypse, and the team deciding he was the perfect fit for Ryuji. He was also portrayed by motion actor and dancer Yu Jurry, who also had to perform as another Persona character who was similar to Ryuji, and thus had to ensure that their dances were unique to each other. He has portrayed Ryuji in later games, such as Persona 5 Strikers and Persona 5 Tactica, and in adaptations of Persona 5.

Yusuke Kitagawa (喜多川 祐介, Kitagawa Yūsuke) is a character in the 2016 video game Persona 5. He is one of its main characters, being a member of the group Phantom Thieves of Hearts, who aim to change the hearts of those who do wrong to others. He is an eccentric artist who works under the tutelage of Ichiryusai Madarame, a prestigious artist, who becomes a target of the Phantom Thieves after hearing that he was abusing his students, and that he had killed Yusuke's mother.