Actors from Knoxville, Tennessee

Christina Rene Hendricks (born May 3, 1975) is a British-American actress and former model. Her accomplishments include six Primetime Emmy Award nominations, two Screen Actors Guild Awards, and two Critics' Choice Awards for Best Supporting Actress in a Drama Series. A 2010 poll of female readers taken by Esquire magazine named her "the sexiest woman in the world," and voted as Best Looking Woman in America the same year.

Brad Barron Renfro (July 25, 1982 – January 15, 2008) was an American actor. Renfro made his film debut at the age of 11 with a starring role in The Client (1994), and went on to appear in 21 feature films.

Patricia Neal (born Patsy Louise Neal, January 20, 1926 – August 8, 2010) was an American actress of stage and screen. She was best known for her film roles as World War II widow Helen Benson in The Day the Earth Stood Still (1951), wealthy matron Emily Eustace Failenson in Breakfast at Tiffany's (1961), and the worn-out housekeeper Alma Brown in Hud (1963), for which she won the Academy Award for Best Actress. She featured as the matriarch in the television film The Homecoming: A Christmas Story (1971); her role as Olivia Walton was re-cast for the series it inspired, The Waltons.

Morgan Stevens (October 16, 1951 – c. January 26, 2022) was an American actor, primarily seen on television.

Mary Lamar Rickey (27 October 1938 - 12 October 2023), better known as Lara Parker, was an American television, stage, and film actress known for her role as Angelique on the ABC-TV serial Dark Shadows which aired from 1966 to 1971.

Jake Thomas (born January 30, 1990) is an American actor, voice actor and photographer, perhaps best known for his role as Matt McGuire, the title character's younger brother, in the Disney Channel show Lizzie McGuire (2001–04). In 2002, he won a Young Artist Award for supporting actor for his performance in A.I. Artificial Intelligence (2001). He also appeared in Cory in the House (2007–08), playing the role of Jason Stickler.

David Lemuel Keith (born May 8, 1954) is an American actor and director. His breakthrough role was that of aspiring Navy pilot Sid Worley in An Officer and a Gentleman (1982), for which he was nominated for two Golden Globe Awards. The positive reception for this role led to leading parts in the films The Lords of Discipline (1983), Firestarter (1984) and White of the Eye (1987). Keith had notable supporting roles in features including Major League II (1994), The Indian in the Cupboard (1995), U-571 (2000), Men of Honor (2000) and Daredevil (2003).

Christopher W. Douglas (born August 29, 1969 in Knoxville, Tennessee, U.S.) is an actor, best known for roles on the soap operas One Life to Live as Dylan Moody (1994–1997, 2000) and Passions as Antonio Lopez-Fitzgerald (2001–2004, 2008). in 1994 he appeared in Tori Amos music video for her song Cornflake Girl.

Lillian Randolph (1914/1915 – September 12, 1980) was an American actress and singer, a veteran of radio, film, and television. She worked in entertainment from the 1930s until shortly before her death. She appeared in hundreds of radio shows, motion pictures, short subjects, and television shows.

Diana Dale Dickey (born September 29, 1961) is an American actress who has worked in theater, film, and television. Dickey won the Independent Spirit Award for Best Supporting Female for her performance as Merab in the 2010 independent drama film Winter's Bone. She is also known for her character roles in a number of mainstream and independent films as of the early 2000s, and for recurring performances in television shows such as My Name Is Earl, Breaking Bad, True Blood and Justified. She also appeared on the television series Vice Principals on HBO.