2021 American television series debuts

Si nos dejan (English: If They Let Us) is a Mexican telenovela produced by W Studios for Televisa. The series is an adaptation of the 1993 Colombian telenovela Señora Isabel, which most recent popular version was Victoria. The series first aired in the United States on Univision from 1 June 2021 to 11 October 2021. In Mexico, the series aired on Las Estrellas from 1 November 2021 to 20 February 2022.

The Game is an American comedy-drama television series created by Mara Brock Akil. Premiering on October 1, 2006, the series debuted as the only new comedy series chosen for The CW's primetime schedule. Along with Runaway, it was one of only two series on the new network not to be inherited from either of its predecessor networks, The WB and UPN, during the network's first season. The series is a spin-off of the long-running UPN/CW sitcom Girlfriends.

America's Most Wanted (often abbreviated as AMW) is an American television program whose first run was produced by 20th Television, and second run is under the Fox Alternative Entertainment division of Fox Corporation. At the time of its cancellation by the Fox television network in June 2011, it was the longest-running program in the network's history (24 seasons), a mark since surpassed by The Simpsons, although the program was revived ten years later. The show started off as a half-hour program on February 7, 1988. In 1990, the show's format was changed from 30 minutes to 60 minutes. The show's format was reverted to 30 minutes in 1995, and then back to 60 minutes in 1996. A short-lived syndicated spinoff titled America's Most Wanted: Final Justice aired during the 1995–96 season.

Diseñando tu amor is a Mexican telenovela that premiered on Las Estrellas and Univision on 26 April 2021. The series is produced by Pedro Ortiz de Pinedo. It is an adaptation of the Portuguese telenovela Meu Amor created by António Barreira, and stars an ensemble cast lead by Gala Montes, Juan Diego Covarrubias, Sergio Goyri, Ana Belena, Osvaldo de León, and María Sorté. The series revolves around Valentina (Gala Montes) and Nora (Ale Müller), two sisters, with different personalities, who share the desire to stand out in the world of the fashion industry.

Monster Garage is an American television series aired on the Discovery Channel and hosted by Jesse James. Each episode was an hour in length and was conceived and produced (along with James) by Thom Beers.

MTV Cribs (also known as Cribs) is a documentary television program that originated on MTV and features tours of the private homes of celebrities. MTV currently produces short-form episodes of the program and distributes it through Snapchat Discover.

Hoy Día (Today) is an American Spanish-language morning television show broadcast by Telemundo. The show is broadcast from Telemundo Center in Miami, and is hosted by Penélope Menchaca, Andrea Meza, Lisette Eduardo, Daniel Arenas, Danilo Carrera and Carlos Calderon.

Buscando a Frida (English title: The Search for Frida) is an American drama television series that premiered on Telemundo on 26 January 2021. The series is an adaptation of the Chilean telenovela titled ¿Dónde está Elisa? created by Pablo Illanes, which Telemundo had adapted in 2010 with the same name. It stars Eduardo Santamarina, Ximena Herrera, and Arap Bethke.

Toon In with Me is an American live-action/animated anthology television series created by Neal Sabin for MeTV and MeTV Plus. A special preview episode aired on January 1, 2021, with the main series officially debuting on January 4, 2021.

Big Shot is an upcoming American sports dramedy streaming television series developed by Dean Lorey and David E. Kelley based on an original idea by Brad Garrett for Disney+ starring John Stamos in the lead role. The series is scheduled to premiere on April 16, 2021.