2003 USC Trojans football—AP national champions

Reginald Alfred Bush Jr. (born March 2, 1985) is a former American football running back. He played college football at USC, where he earned consensus All-American honors twice and won the Heisman Trophy as the most outstanding player in the nation. He was drafted by the New Orleans Saints second overall in the 2006 NFL Draft. While with the Saints, Bush was named an All-Pro punt returner in 2008 and won Super Bowl XLIV in 2010 over the Indianapolis Colts. He also played for the Buffalo Bills, Miami Dolphins, Detroit Lions, and San Francisco 49ers.

Matthew Stephen Leinart (born May 11, 1983) is a former American football quarterback who now works as a studio analyst for Fox Sports’ college football coverage. He played college football at the University of Southern California (USC) from 2001 to 2005. He was the starting quarterback for the Trojans in 2003, 2004, and 2005. As junior in 2004, he won the Heisman Trophy. Leinart played professionally in the National Football League (NFL) for the Arizona Cardinals (2006–2009), Houston Texans (2010–2011), Oakland Raiders (2012), and Buffalo Bills (2013). Leinart signed a deal with the Pac-12 Network, making his official debut as a Studio Analyst on August 30, 2014. He is a recurring guest, via voicemail, on the Barstool Sports podcast Pardon My Take. Leinart was inducted into the College Football Hall of Fame on December 5, 2017.

Matthew Brennan "Matt" Cassel (born May 17, 1982) is a former American football quarterback. He was drafted by the New England Patriots in the seventh round of the 2005 NFL draft. He played college football at USC. A journeyman quarterback throughout his career, Cassel has also played for the Kansas City Chiefs, Minnesota Vikings, Buffalo Bills, Dallas Cowboys, Tennessee Titans, and Detroit Lions.

Stephen Ambrose Sarkisian (born March 8, 1974) is an American football coach and former player who is the current offensive coordinator for the Alabama Crimson Tide. He was previously the offensive coordinator for the Atlanta Falcons of the National Football League (NFL) He has also served as the head football coach of the University of Washington from 2009 to 2013 and at the University of Southern California (USC) from 2014 to 2015. He played college football as a quarterback at Brigham Young University (BYU) and professionally with the Saskatchewan Roughriders of the Canadian Football League (CFL).

Lane Monte Kiffin (born May 9, 1975) is an American football coach and former player. He is currently the offensive coordinator at the University of Alabama. He formerly served as the offensive coordinator for the USC Trojans football team from 2005 to 2006, head coach of the National Football League's Oakland Raiders from 2007 to 2008, head coach of the University of Tennessee Volunteers college football team in 2009, and head coach of the USC Trojans from 2010 to 2013. Kiffin was the youngest head coach in NFL history when he joined the Raiders, and for a time was the youngest head coach of a BCS Conference team in college football. He is the son of longtime NFL defensive coordinator Monte Kiffin, who was most recently the assistant head coach/defense for the Dallas Cowboys.

Frostee Lynn Rucker (born September 14, 1983) is a former American football defensive lineman. He played college football at USC, and was drafted by the Cincinnati Bengals in the third round of the 2006 NFL Draft. Rucker has also played for the Cleveland Browns, Arizona Cardinals, and Oakland Raiders.

Fred Matua (January 14, 1984 – August 5, 2012) was an American football guard. After playing college football for Southern California, he was drafted by the Detroit Lions in the seventh round of the 2006 NFL Draft. He was a member of the Lions, Tennessee Titans, Cleveland Browns, Washington Redskins, Florida Tuskers, and Omaha Nighthawks in his career.

Hershel Dennis Jr. (born July 12, 1984) is a former American football running back. He played college football as a student athlete at the University of Southern California. During his six-year career, the Trojans went 70–8 making Dennis the first player to play on six Pacific-10 Championship squads and the player with the most wins in college football history. His nickname since childhood is "Patch"

Nicholas Holt V (born October 15, 1962) is a college football coach. Prior to taking the defensive coordinator position at Western Kentucky in 2013, he was the defensive coordinator and assistant head coach of the Washington Huskies for three seasons. Previously, Holt was the defensive coordinator and defensive line coach of the USC Trojans, and the head coach of the Idaho Vandals from 2004 to 2005.

John David Booty (born January 3, 1985) is a former American football quarterback. He played college football at USC and was drafted by the Minnesota Vikings in the fifth round of the 2008 NFL Draft.