The Big Empty is a 2003 drama film directed and written by Steve Anderson. It stars Jon Favreau as a struggling actor with a bizarre request from his neighbor to deliver a suitcase that he cannot open. While there, he meets an unusual cast of characters, and starts to think this delivery might be more than it seems. Wikipedia
(last lines) John Person: You look different tonight. Grace: It's the tenth frame, you get one more chance. Make it count. Then we start a new game.