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Sara Gilbert (Leslie) who plays a former girlfriend of Leonard's, also played Johnny Galecki's girlfriend in "Roseanne" (1988). Laurie Metcalf, who plays Sheldon's mother, was also his co-star in Roseanne.


The two main characters (Sheldon Cooper and Leonard Hofstadter) are named after Sheldon Leonard.


The theme song by the Barenaked Ladies has two more verses and a bridge. The full length of the song is 1:45 (a live version runs 2:20).


While Wil Wheaton was appearing on the show, he took a photo of the set's coffee table and posted it on his much-followed blog. Among the materials on the coffee table were: copies of "Mental Floss" magazine; The Sandman Vol. 6: Fables and Reflections by Neil Gaiman; a package of Pepperidge Farm Sausalito milk chocolate macadamia nut chunk cookies; a package of Redvines licorice; and a package of Tim's brand Original Flavor lightly salted potato chips.


The names of all the episodes relate to various scientific terminology, and even bear relation to the events of the episode.


The original working title of the show was "Lenny, Penny, and Kenny."


Sheldon occasionally wears t-shirts featuring a specific color with a corresponding symbol. These shirts are from the "Green Lantern" comic book series, with each color representing a different corps of heroes or villains (e.g. Red Lanterns, Orange Lanterns, etc). In the comics, each color also represents a specific emotion: Red=Anger, Orange=Greed, Yellow=Fear, Green=Willpower/Courage, Blue=Hope, Indigo=Compassion, and Violet=Love. Not surprisingly, the color of shirt Sheldon wears in each scene is often a clue to his mood.


Despite the fact that some viewers take Sheldon's behavior, mannerisms, and social skills as a sign that Sheldon has Asperger's Syndrome or otherwise falls on the "Autism spectrum," the show-runners have persistently denied in many interviews that Sheldon has Asperger's or Autism.


There are no traditional exterior shots when transitioning to the next scene.


Recurring guest Mayim Bialik is the only cast member to have a PhD. In 2008, she completed her neuroscience studies.


On 14 January 2011, CBS gave the series a rare vote of confidence when it issued a three-year renewal through the 2013-14 season.


Most of the time Leonard has no glass in his glasses.


Leonard's last name, Hofstadter, refers to two well-known scientists: Robert Hofstadter, the 1961 Nobel Laureate in Physics, and his son Douglas Hofstadter, who researches consciousness and cognition, and whose best-selling book about philosophy, mathematics, puzzles, art, and music, "Gödel, Escher, Bach: an Eternal Golden Braid," was published in 1979 and won him the 1980 Pulitzer Prize for general nonfiction.


On January 3, 2013, it was announced that a team of Brazilian Biologists named a newly discovered type of orchid bee that was eventually named Euglossa bazinga. This was to honor the show and specifically Sheldon's catchphrase "bazinga." Executive producer Steven Molaro responded in a press release: "We are always extremely flattered when the science community embraces our show. Sheldon would be honored to know that Euglossa bazinga was inspired by him. In fact, after Mothra (1961) and griffins, bees are his third-favorite flying creature."


Sheldon verbally reveals his and Leonard's Pasadena apartment 4A's location as being 2311 Los Robles in "The Desperation Emanation." In the 100th episode, Sheldon also reveals that their apartment building is across the street from the Colorado Avenue Chevron gas station, making their building a corner location, on the corner of Los Robles and Colorado. There are two incidences of this intersection in southern California, both located in Los Angeles County, the first one is E. Colorado Boulevard & N. Los Robles Avenue, Pasadena, CA 91101, and the second one is Colorado Boulevard & Los Robles Street, Los Angeles, CA 90041. However, 2311 Los Robles is not an address by either one of those intersections. Leonard does reveal, however, that they live in Pasadena while declaring himself the Darth Vader of Pasadena.


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