Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are inside the live-action ones: the film is set in a fictionalized version of the human body which resembles a large city, where micro-organisms or any being based in organisms are anthropomorphic and centers on Frank Detorre, a slovenly zookeeper. Osmosis Jones, a white blood cell, teams up with Drix, a cold pill, against Thrax, a deadly virus who plans to kill Frank in forty-eight hours and other characters living within him. Wikipedia
Osmosis: Yo, where do you think you're going? Drix: To get our cootie. Osmosis: Looking like that? They'll tear you apart. You gotta get spiffy. Drix: Spiffy? (Osmosis rearranges himself to look like a germ) Osmosis: Check it out! Drix: Hmm. Flexible cellular dynamics. What an ingenious defense mechanism. Ooh, let me try! (Drix tries, only succedes in mangling his face) Drix: What do you think? Osmosis: I think you should guard the car.