SPOILER: All vehicles driven by the main characters are Fords. There is the Ford/Shelby GT500 Mustang that Neville drives in the beginning, the Ford Expedition he drives throughout the film, and the Ford Escape used to depart New York at the end.
In one scene in the deserted street a billboard in the background can be seen. It is the Superman logo over the Batman logo, insinuating a movie tie-in or face-off has been filmed.
In the last scene of the movie, Anna and Ethan are driving through the autumn countryside. This scene was filmed in East Amwell, New Jersey because in the original filming place, the leaves on the trees had already fallen off.
At the New York premiere, Will Smith apologized for the disruption shooting the movie caused to the city residents. He said, "I would like to issue a public apology to the citizens of New York. There were a couple of streets we had to close off during the filming of 'I Am Legend'. I am very sorry. People were kind of upset with me."
In the scene in Times Square, there is a billboard for the Justice League: Mortal movie set to open May 10th, 2010. Also in the video store, posters for the live action adaptations of Teen Titans and Green Lantern.
The studio spent an estimated $5 million for a six-night shoot in New York City involving the Brooklyn Bridge. To film in this location, the producers needed the approval of as many as 14 government agencies. The shooting required a crew of 250, plus 1,000 extras, including 160 National Guard troops in full combat gear.
Warner Bros. gained the rights to the novel by Richard Matheson in the 1970s and produced a version of it, called The Omega Man (1971), in 1971. Previous to that, Associated Producers did an adaptation in 1964 called The Last Man on Earth (1964) with Vincent Price, shot in Italy and directed by Italian Ubaldo Ragona and American Sidney Salkow. Although Matheson did not contribute to the screenplay of the 1964 film--which took a critical drubbing--he did contribute to the screenplay for this film.
# # Nicolas Cage was considered for the role of Robert Neville back in 1998 along with director Rob Bowman, who was eventually moved on to direct The X Files (1998).
In the film, Will Smith (I)''s character holds up a CD, calling it "the best album ever made." The album is Bob Marley's "Legend." It is a greatest hits compilation that was released after Marley's death.
Although the creatures are referred to as Dark Seekers, during the film, if watched with the subtitles on (DVD) they are called Hemocytes.
Ted Levine and Tom Cruise were also considered for the role of Robert Neville.
While doing a press conference in Japan for the release of the movie, Will Smith accidentally revealed the ending to a collection of entertainment reporters. Warner Brothers asked the reporters and all those present to withhold the ending and the reporters all obliged without any payoff or consideration.
# # Will Smith grew so enamored of his canine co-star, Abby, that he tried to adopt her when the shooting was finished, but the dog's trainer could not be persuaded to give her up.
Release prints were delivered to theaters with the fake title 'Blood Allies'.
All of the paintings in Dr. Neville's house were provided by the Museum of Modern Art in New York City.