How to Lose a Guy in 10 Days is a 2003 romantic comedy film directed by Donald Petrie, starring Kate Hudson and Matthew McConaughey. It is based on a short cartoon book of the same name by Michele Alexander and Jeannie Long. Wikipedia
(Andie is holding a tissue in front of Ben's face)
Andie: C'mon, blow. Nobody likes a Mr. Sniffles.
Tony: Yeah, uh, I hate Mr. Sniffles.