14 May 1996 - 4 December 2015) (divorced) (1 child)
Griffith then fell in love with Antonio Banderas, her married co-star from Two Much. After their respective divorces were finalized, Griffith and Banderas married on May 14, 1996. Their daughter, Stella Del Carmen Banderas, was born on September 24, 1996.
In 2000, Griffith returned to rehab for treatment of a painkiller addiction. In August 2009, Griffith returned to rehab again for what her publicist called "part of a routine plan." She had a three-month stay. In December of that year, she had surgery for skin cancer.
In June 2014, Griffith and Banderas released a statement announcing their intention to divorce "in a loving and friendly manner." According to the petition filed in the Los Angeles Superior Court, the couple had "irreconcilable differences" that led to the divorce. In December 2015, their divorce was finalized. Banderas has stated that he will always love Griffith, and Griffith appeared alongside Banderas in the 2014 film Automata, which they filmed amidst their divorce proceedings.